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The Master Switch: The Rise and Fall of Information Empires

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The Solid State Isolator contains two isolation circuits. The first breaks the connection between the negative side of the vehicle’s battery from chassis/earth, thereby isolating the battery power from all electrical circuits, while the second cuts power to the engine electrics and thereby stops the engine from running. SPDT switches are not required if only needs master OFF function, an SPST switch is enough for that. Because only one throw is required in this circuit. Master ON and Master OFF switching

Here circuit has the combined functionality of master ON switch and Master OFF switch wiring. This wiring arrangement can turn ON or OFF lamps irrespective of their individual switch positions. The Isolator can be controlled by any number of switches although the usual configuration is one internal on- off switch and one external kill button. However, our system also allows multiple kill switches to be installed and the fitment of two external ‘kill’ buttons, one on each side of a race car, has become popular safety feature. This study is an elegant demonstration of how important events in gene regulation – here the control of genes in fat tissue – can be uncovered through large-scale genomics. This is new biological understanding that could be clinically relevant.”

In the circuit, the Master switch (MS1) is an SPST switch and S1, S2, S3, S4 are SPDT switches. The common pole of each SPDT switches S1 to S4 are connected to the respective lamps L1 to L4, also the neutral line is distributed parallel to each lamp. The KLF14 gene is special in that its activity is inherited from the mother. Each person inherits a set of all genes from both parents. But in this case, the copy of KLF14 from the father is switched off, meaning that the copy from the mother is the active gene – a process called imprinting. Moreover, the ability of KLF14 to control other genes was entirely dependent on the copy of KLF14 inherited from the mother – the copy inherited from the father had no effect.

In apartments and private houses, it guarantees that all lights and household appliances have been turned off. At industrial facilities, it saves the time of employees responsible for closing up at the end of the working day.

Master ON and Master OFF switching

In the event of a fault, MMS guarantees switching time between the 2 power sources of less than a quarter of a cycle (< 4 msec for synchronised inputs; < 10 msec for non-synchronised). This is the case for both automatic and manually-triggered switches. The researchers examined over 20,000 genes in subcutaneous fat biopsies from 800 UK female twin volunteers. They found an association between the KLF14 gene and the expression levels of multiple distant genes found in fat tissue, which means it acts as a master switch to control these genes. This was then confirmed in a further independent sample of 600 subcutaneous fat biopsies from Icelandic subjects. This is the first major study that shows how small changes in one master regulator gene can cause a cascade of other metabolic effects in other genes. This has great therapeutic potential particularly as by studying large detailed populations such as the twins we hope to find more of these regulators.” It is one of the largest biomedical research centres in Europe, with over 2,500 people involved in research and more than 2,800 students, and brings in around two-thirds of Oxford University’s external research income. Listed by itself, that would make it the fifth largest university in the UK in terms of research grants and contracts.

King’s College London and Guy’s and St Thomas’, King’s College Hospital and South London and Maudsley NHS Foundation Trusts are part of King’s Health Partners. King’s Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world’s leading research-led universities and three of London’s most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services.In offices, stores and other businesses, it eases the work of the manager and ensures energy savings.

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